Real-time clinical decision support to prevent adverse drug events in complex polypharmacy. Enter any two medications to instantly surface contraindications, severity ratings, and evidence-based management guidance.
Common interactions to check:
⚠️ Clinical Disclaimer
The MedaDose Rx Interactions Hub is intended for use as an educational tool and reference guide only. It does not replace the professional judgment of a prescribing physician or clinical pharmacist. Not all possible drug interactions are listed — our database covers a curated set of clinically significant pairs. Drug interactions can vary based on individual patient factors including renal and hepatic function, age, weight, genetics, and comorbidities. Always consult a healthcare provider before starting, stopping, or altering any medication regimen. In a medical emergency, contact your local emergency services immediately.
Adverse drug events are among the most preventable causes of patient harm in modern healthcare. According to the FDA and CDC, ADEs cause over 1.3 million emergency department visits annually in the United States alone — and an estimated 125,000 deaths per year are attributable to medication non-adherence and drug interactions combined.
As patient regimens become increasingly complex — driven by the rise of specialized biologics, GLP-1 receptor agonists, oncology protocols, and multi-drug chronic disease management — automated interaction checking is no longer optional. It is a clinical standard of care. The MedaDose Rx Interactions Hub is designed to make that standard accessible to every caregiver, pharmacist, and prescriber, at the point of decision.
Polypharmacy — the concurrent use of five or more prescription medications — is now the norm rather than the exception in older adults. Studies show that 40% of adults over 65 take five or more prescription drugs, and nearly 20% take ten or more. With each additional medication added to a regimen, the number of potential drug-to-drug interaction pairs grows exponentially.
A patient on five medications has 10 possible two-drug interaction pairs. A patient on ten medications has 45. The cognitive burden of manually cross-referencing all of these pairs in a clinical setting is unrealistic — which is precisely why tools like the MedaDose Rx Interactions Hub exist. By instantly flagging high-risk contraindications, we reduce the cognitive load on clinicians and empower caregivers to make safer, more informed decisions at home.
Not all drug interactions carry the same clinical weight. Our severity ratings follow the classification system used by major pharmacological references including the FDA, Drugs.com, and the ASHP Drug Interaction Database.
High Risk
Combination should generally be avoided. Risk of serious adverse events including bleeding, cardiac arrhythmia, renal failure, or serotonin syndrome. Requires immediate clinical review.
Moderate
Use with caution. The combination may require dose adjustment, increased monitoring, or timing modifications. Discuss with your prescriber or pharmacist.
Minor
Interaction exists but is unlikely to cause significant clinical harm in most patients. Monitor for mild side effects and report any unusual symptoms.
1.3M
ED visits annually from adverse drug events
FDA / CDC
40%
of adults 65+ take 5 or more prescription drugs
AARP Research
45
possible interaction pairs in a 10-drug regimen
Clinical Pharmacology
70%
of ADEs are considered preventable
NEJM 2022
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